Objective: Drug allergy labels are common in clinical practice; however, misconceptions, insufficient knowledge, and inadequate management may negatively affect patient safety and healthcare utilization. Data regarding patient knowledge, attitudes, and perspectives on drug allergy remain limited, particularly among adults with suspected drug hypersensitivity.

Materials and Methods: In this cross-sectional survey study, 189 adult patients referred to a tertiary Allergy and Immunology outpatient clinic for suspected drug allergy between September and November 2025 were enrolled. Data were collected using a structured questionnaire assessing demographics, knowledge regarding drug allergy, attitudes toward drug allergy, and patient perspectives on drug allergy management. Knowledge scores ranged from 0-10, and attitude scores were calculated using a 5-point Likert scale. Associations between demographic and clinical variables and questionnaire outcomes were analyzed using non-parametric tests, correlation analyses, and multivariable linear regression.

Results: The median age of the participants was 40 years, and 59.6% were female. The median knowledge score was 8/10, with 9.0% of participants answering all knowledge questions correctly. Higher educational attainment was significantly associated with better knowledge scores (p<0.001), whereas increasing age was negatively correlated with knowledge level (ρ=−0.244, p<0.001). Knowledge and attitude scores showed a weak positive correlation (ρ=0.169, p=0.020). Only 18.0% of participants reported written confirmation of their drug allergy diagnosis, and 27.5% had received written information regarding safe alternative medications. Although 78.3% expressed willingness to undergo drug provocation testing, 16.4% reported rarely or never disclosing their drug allergy history during healthcare visits.

Conclusion: Adults with suspected drug hypersensitivity demonstrated generally favorable knowledge and attitudes regarding drug allergy; however, substantial gaps remain in documentation, communication, and patient-centered management practices. These findings highlight the need for improved education, standardized documentation, and broader implementation of specialist-guided drug allergy evaluation to optimize long-term patient safety.